| Name : R-NNTbiomarker
| |
| Version : 0.29.11
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp154.14.1
| Date : 2024-06-08 01:39:39
|
| Group : Development/Libraries/Other
| Source RPM : R-NNTbiomarker-0.29.11-lp154.14.1.src.rpm
|
| Size : 0.87 MB
| |
| Packager : https://www_suse_com/
| |
| Summary : Calculate Design Parameters for Biomarker Validation Studies
|
Description :
Helps a clinical trial team discuss the clinical goals of a
well-defined biomarker with a diagnostic, staging, prognostic, or
predictive purpose. From this discussion will come a statistical plan
for a (non-randomized) validation trial. Both prospective and
retrospective trials are supported. In a specific focused discussion,
investigators should determine the range of \"discomfort\" for the NNT,
number needed to treat. The meaning of the discomfort range,
[NNTlower, NNTupper], is that within this range most physicians would
feel discomfort either in treating or withholding treatment. A pair of
NNT values bracketing that range, NNTpos and NNTneg, become the targets
of the study\'s design. If the trial can demonstrate that a positive
biomarker test yields an NNT less than NNTlower, and that a negative
biomarker test yields an NNT less than NNTlower, then the biomarker may
be useful for patients. A highlight of the package is visualization of
a \"contra-Bayes\" theorem, which produces criteria for retrospective
case-controls studies.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/15.4/x86_64 |
