| Name : R-RestoreNet
| |
| Version : 1.0.1
| Vendor : obs://build_opensuse_org/devel:languages:R
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| Release : lp154.4.1
| Date : 2024-09-10 18:59:43
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| Group : Development/Libraries/Other
| Source RPM : R-RestoreNet-1.0.1-lp154.4.1.src.rpm
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| Size : 0.55 MB
| |
| Packager : https://www_suse_com/
| |
| Summary : Random-Effects Stochastic Reaction Networks
|
Description :
A random-effects stochastic model that allows quick detection of clonal
dominance events from clonal tracking data collected in gene therapy
studies. Starting from the Ito-type equation describing the dynamics of
cells duplication, death and differentiation at clonal level, we first
considered its local linear approximation as the base model. The
parameters of the base model, which are inferred using a maximum
likelihood approach, are assumed to be shared across the clones.
Although this assumption makes inference easier, in some cases it can
be too restrictive and does not take into account possible scenarios of
clonal dominance. Therefore we extended the base model by introducing
random effects for the clones. In this extended formulation the dynamic
parameters are estimated using a tailor-made expectation maximization
algorithm. Further details on the methods can be found in L. Del Core
et al., (2022) < doi:10.1101/2022.05.31.494100>.
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RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/15.4/x86_64 |
