| Name : R-CKLRT
| |
| Version : 0.2.3
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp155.3.4
| Date : 2024-09-10 18:10:53
|
| Group : Development/Libraries/Other
| Source RPM : R-CKLRT-0.2.3-lp155.3.4.src.rpm
|
| Size : 0.53 MB
| |
| Packager : https://www_suse_com/
| |
| Summary : Composite Kernel Machine Regression Based on Likelihood Ratio Test
|
Description :
Composite Kernel Machine Regression based on Likelihood Ratio Test
(CKLRT): in this package, we develop a kernel machine regression
framework to model the overall genetic effect of a SNP-set, considering
the possible GE interaction. Specifically, we use a composite kernel to
specify the overall genetic effect via a nonparametric function and we
model additional covariates parametrically within the regression
framework. The composite kernel is constructed as a weighted average of
two kernels, one corresponding to the genetic main effect and one
corresponding to the GE interaction effect. We propose a likelihood
ratio test (LRT) and a restricted likelihood ratio test (RLRT) for
statistical significance. We derive a Monte Carlo approach for the
finite sample distributions of LRT and RLRT statistics. (N. Zhao, H.
Zhang, J. Clark, A. Maity, M. Wu. Composite Kernel Machine Regression
based on Likelihood Ratio Test with Application for Combined Genetic
and Gene-environment Interaction Effect (Submitted).)
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/15.5/x86_64 |
