| Name : R-LEGIT
| |
| Version : 1.4.1
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp155.4.1
| Date : 2024-06-21 11:11:42
|
| Group : Development/Libraries/Other
| Source RPM : R-LEGIT-1.4.1-lp155.4.1.src.rpm
|
| Size : 1.17 MB
| |
| Packager : https://www_suse_com/
| |
| Summary : Latent Environmental & Genetic InTeraction (LEGIT) Model
|
Description :
Constructs genotype x environment interaction (GxE) models where G is a
weighted sum of genetic variants (genetic score) and E is a weighted
sum of environments (environmental score) using the alternating
optimization algorithm by Jolicoeur-Martineau et al. (2017)
< arXiv:1703.08111>. This approach has greatly enhanced predictive power
over traditional GxE models which include only a single genetic variant
and a single environmental exposure. Although this approach was
originally made for GxE modelling, it is flexible and does not require
the use of genetic and environmental variables. It can also handle more
than 2 latent variables (rather than just G and E) and 3-way
interactions or more. The LEGIT model produces highly interpretable
results and is very parameter-efficient thus it can even be used with
small sample sizes (n < 250). Tools to determine the type of
interaction (vantage sensitivity, diathesis-stress or differential
susceptibility), with any number of genetic variants or environments,
are available < arXiv:1712.04058>. The software can now produce
mixed-effects LEGIT models through the lme4 package.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/15.5/x86_64 |
