| Name : R-pKSEA
| |
| Version : 0.0.1
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp156.2.1
| Date : 2024-06-24 14:06:01
|
| Group : Development/Libraries/Other
| Source RPM : R-pKSEA-0.0.1-lp156.2.1.src.rpm
|
| Size : 2.83 MB
| |
| Packager : https://www_suse_com/
| |
| Summary : Prediction-Based Kinase-Substrate Enrichment Analysis
|
Description :
A tool for inferring kinase activity changes from phosphoproteomics
data. \'pKSEA\' uses kinase-substrate prediction scores to weight
observed changes in phosphopeptide abundance to calculate a
phosphopeptide-level contribution score, then sums up these
contribution scores by kinase to obtain a phosphoproteome-level kinase
activity change score (KAC score). \'pKSEA\' then assesses the
significance of changes in predicted substrate abundances for each
kinase using permutation testing. This results in a permutation score
(pKSEA significance score) reflecting the likelihood of a similarly
high or low KAC from random chance, which can then be interpreted in an
analogous manner to an empirically calculated p-value. \'pKSEA\' contains
default databases of kinase-substrate predictions from \'NetworKIN\'
(NetworKINPred_db) < http://networkin.info> Horn, et. al (2014)
< doi:10.1038/nmeth.2968> and of known kinase-substrate links from
\'PhosphoSitePlus\' (KSEAdb) < https://www.phosphosite.org/> Hornbeck PV,
et. al (2015) < doi:10.1093/nar/gku1267>.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/15.6/x86_64 |
