| Name : R-COMBAT
| |
| Version : 0.0.4
| Vendor : obs://build_opensuse_org/devel:languages:R
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| Release : lp153.2.13
| Date : 2024-06-14 11:14:22
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| Group : Development/Libraries/Other
| Source RPM : R-COMBAT-0.0.4-lp153.2.13.src.rpm
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| Size : 0.03 MB
| |
| Packager : (none)
| |
| Summary : A Combined Association Test for Genes using Summary Statistics
|
Description :
Genome-wide association studies (GWAS) have been widely used for
identifying common variants associated with complex diseases. Due to
the small effect sizes of common variants, the power to detect
individual risk variants is generally low. Complementary to SNP-level
analysis, a variety of gene-based association tests have been proposed.
However, the power of existing gene-based tests is often dependent on
the underlying genetic models, and it is not known a priori which test
is optimal. Here we proposed COMBined Association Test (COMBAT) to
incorporate strengths from multiple existing gene-based tests,
including VEGAS, GATES and simpleM. Compared to individual tests,
COMBAT shows higher overall performance and robustness across a wide
range of genetic models. The algorithm behind this method is described
in Wang et al (2017) < doi:10.1534/genetics.117.300257>.
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RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
