| Name : R-DSviaDRM
| |
| Version : 1.0
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp153.2.13
| Date : 2024-06-14 11:40:37
|
| Group : Development/Libraries/Other
| Source RPM : R-DSviaDRM-1.0-lp153.2.13.src.rpm
|
| Size : 2.34 MB
| |
| Packager : (none)
| |
| Summary : Exploring Disease Similarity in Terms of Dysfunctional Regulatory Mechanisms
|
Description :
Elucidation of human disease similarities has emerged as an active
research area, which is highly relevant to etiology, disease
classification, and drug repositioning. This package was designed and
implemented for identifying disease similarities. It contains five
functions which are \'DCEA\', \'DCpathway\', \'DS\', \'comDCGL\' and
\'comDCGLplot\'. In \'DCEA\' function, differentially co-expressed genes
and differentially co-expressed links are extracted from disease vs.
health samples. Then \'DCpathway\' function assigns differential
co-expression values of pathways to be the average differential
co-expression value of their component genes. Then \'DS\' employs partial
correlation coefficient of pathways as the disease similarity for each
disease pairs. And \'DS\' contains a permutation process for evaluating
the statistical significant of observed disease partial correlation
coefficients. At last, \'comDCGL\' and \'comDCGLplot\' sort out shared
differentially co-expressed genes and differentially co-expressed links
with regulation information and visualize them.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
