| Name : R-Haplin
| |
| Version : 7.3.2
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp153.1.1
| Date : 2024-09-10 01:40:19
|
| Group : Development/Libraries/Other
| Source RPM : R-Haplin-7.3.2-lp153.1.1.src.rpm
|
| Size : 4.35 MB
| |
| Packager : (none)
| |
| Summary : Analyzing Case-Parent Triad and/or Case-Control Data with SNP Haplotypes
|
Description :
Performs genetic association analyses of case-parent triad (trio) data
with multiple markers. It can also incorporate complete or incomplete
control triads, for instance independent control children. Estimation
is based on haplotypes, for instance SNP haplotypes, even though phase
is not known from the genetic data. \'Haplin\' estimates relative risk
(RR + conf.int.) and p-value associated with each haplotype. It uses
maximum likelihood estimation to make optimal use of data from triads
with missing genotypic data, for instance if some SNPs has not been
typed for some individuals. \'Haplin\' also allows estimation of effects
of maternal haplotypes and parent-of-origin effects, particularly
appropriate in perinatal epidemiology. \'Haplin\' allows special models,
like X-inactivation, to be fitted on the X-chromosome. A GxE analysis
allows testing interactions between environment and all estimated
genetic effects. The models were originally described in \"Gjessing HK
and Lie RT. Case-parent triads: Estimating single- and double-dose
effects of fetal and maternal disease gene haplotypes. Annals of Human
Genetics (2006) 70, pp. 382-396\".
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
