| Name : R-SEAGLE
| |
| Version : 1.0.1
| Vendor : obs://build_opensuse_org/devel:languages:R
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| Release : lp153.1.11
| Date : 2024-06-14 11:17:30
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| Group : Development/Libraries/Other
| Source RPM : R-SEAGLE-1.0.1-lp153.1.11.src.rpm
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| Size : 2.94 MB
| |
| Packager : (none)
| |
| Summary : Scalable Exact Algorithm for Large-Scale Set-Based Gene-Environment Interaction Tests
|
Description :
The explosion of biobank data offers immediate opportunities for
gene-environment (GxE) interaction studies of complex diseases because
of the large sample sizes and rich collection in genetic and
non-genetic information. However, the extremely large sample size also
introduces new computational challenges in GxE assessment, especially
for set-based GxE variance component (VC) tests, a widely used strategy
to boost overall GxE signals and to evaluate the joint GxE effect of
multiple variants from a biologically meaningful unit (e.g., gene). We
present \'SEAGLE\', a Scalable Exact AlGorithm for Large-scale Set-based
GxE tests, to permit GxE VC test scalable to biobank data. \'SEAGLE\'
employs modern matrix computations to achieve the same “exact” results
as the original GxE VC tests, and does not impose additional
assumptions nor relies on approximations. \'SEAGLE\' can easily
accommodate sample sizes in the order of 10^5, is implementable on
standard laptops, and does not require specialized equipment. The
accompanying manuscript for this package can be found at Chi, Ipsen,
Hsiao, Lin, Wang, Lee, Lu, and Tzeng. (2021+) < arXiv:2105.03228>.
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RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
