| Name : R-TITEgBOIN
| |
| Version : 0.3.0
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp153.1.4
| Date : 2024-06-14 11:04:17
|
| Group : Development/Libraries/Other
| Source RPM : R-TITEgBOIN-0.3.0-lp153.1.4.src.rpm
|
| Size : 0.06 MB
| |
| Packager : (none)
| |
| Summary : Time-to-Event Dose-Finding Design for Multiple Toxicity Grades
|
Description :
In some phase I trials, the design goal is to find the dose associated
with a certain target toxicity rate or the dose with a certain weighted
sum of rates of various toxicity grades. \'TITEgBOIN\' provides the set
up and calculations needed to run a dose-finding trial using bayesian
optimal interval (BOIN) (Yuan et al. (2016)
< doi:10.1158/1078-0432.CCR-16-0592>), generalized bayesian optimal
interval (gBOIN) (Mu et al. (2019) < doi:10.1111/rssc.12263>),
time-to-event bayesian optimal interval (TITEBOIN) (Lin et al. (2020)
< doi:10.1093/biostatistics/kxz007>) and time-to-event generalized
bayesian optimal interval (TITEgBOIN) (Takeda et al. (2022)
< doi:10.1002/pst.2182>) designs. \'TITEgBOIN\' can conduct tasks: run
simulations and get operating characteristics; determine the dose for
the next cohort; select maximum tolerated dose (MTD). These functions
allow customization of design characteristics to vary sample size,
cohort sizes, target dose limiting toxicity (DLT) rates or target
normalized equivalent toxicity score (ETS) rates to account for
discrete toxicity score, and incorporate safety and/or stopping rules.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
