| Name : R-UnifiedDoseFinding
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| Version : 0.1.10
| Vendor : obs://build_opensuse_org/devel:languages:R
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| Release : lp153.1.8
| Date : 2024-06-14 11:04:24
|
| Group : Development/Libraries/Other
| Source RPM : R-UnifiedDoseFinding-0.1.10-lp153.1.8.src.rpm
|
| Size : 0.15 MB
| |
| Packager : (none)
| |
| Summary : Dose-Finding Methods for Non-Binary Outcomes
|
Description :
In many phase I trials, the design goal is to find the dose associated
with a certain target toxicity rate. In some trials, the goal can be to
find the dose with a certain weighted sum of rates of various toxicity
grades. For others, the goal is to find the dose with a certain mean
value of a continuous response. This package provides the setup and
calculations needed to run a dose-finding trial with non-binary
endpoints and performs simulations to assess design’s operating
characteristics under various scenarios. Three dose finding designs are
included in this package: unified phase I design (Ivanova et al. (2009)
< doi:10.1111/j.1541-0420.2008.01045.x>), Quasi-CRM/Robust-Quasi-CRM
(Yuan et al. (2007) < doi:10.1111/j.1541-0420.2006.00666.x>, Pan et al.
(2014) < doi:10.1371/journal.pone.0098147>) and generalized BOIN design
(Mu et al. (2018) < doi:10.1111/rssc.12263>). The toxicity endpoints can
be handled with these functions including equivalent toxicity score
(ETS), total toxicity burden (TTB), general continuous toxicity
endpoints, with incorporating ordinal grade toxicity information into
dose-finding procedure. These functions allow customization of design
characteristics to vary sample size, cohort sizes, target dose-limiting
toxicity (DLT) rates, discrete or continuous toxicity score, and
incorporate safety and/or stopping rules.
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RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
