| Name : R-cape
| |
| Version : 3.1.2
| Vendor : obs://build_opensuse_org/devel:languages:R
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| Release : lp153.2.4
| Date : 2024-06-14 12:08:24
|
| Group : Development/Libraries/Other
| Source RPM : R-cape-3.1.2-lp153.2.4.src.rpm
|
| Size : 2.79 MB
| |
| Packager : (none)
| |
| Summary : Combined Analysis of Pleiotropy and Epistasis for Diversity Outbred Mice
|
Description :
Combined Analysis of Pleiotropy and Epistasis infers predictive
networks between genetic variants and phenotypes. It can be used with
standard two-parent populations as well as multi-parent populations,
such as the Diversity Outbred (DO) mice, Collaborative Cross (CC) mice,
or the multi-parent advanced generation intercross (MAGIC) population
of Arabidopsis thaliana. It uses complementary information of
pleiotropic gene variants across different phenotypes to resolve models
of epistatic interactions between alleles. To do this, cape
reparametrizes main effect and interaction coefficients from pairwise
variant regressions into directed influence parameters. These
parameters describe how alleles influence each other, in terms of
suppression and enhancement, as well as how gene variants influence
phenotypes. All of the final interactions are reported as directed
interactions between pairs of parental alleles. For detailed
descriptions of the methods used in this package please see the
following references. Carter, G. W., Hays, M., Sherman, A. & Galitski,
T. (2012) < doi:10.1371/journal.pgen.1003010>. Tyler, A. L., Lu, W.,
Hendrick, J. J., Philip, V. M. & Carter, G. W. (2013)
< doi:10.1371/journal.pcbi.1003270>.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
