| Name : R-mutSignatures
| |
| Version : 2.1.1
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp153.13.5
| Date : 2024-06-14 11:54:10
|
| Group : Development/Libraries/Other
| Source RPM : R-mutSignatures-2.1.1-lp153.13.5.src.rpm
|
| Size : 2.30 MB
| |
| Packager : (none)
| |
| Summary : Decipher Mutational Signatures from Somatic Mutational Catalogs
|
Description :
Cancer cells accumulate DNA mutations as result of DNA damage and DNA
repair processes. This computational framework is aimed at deciphering
DNA mutational signatures operating in cancer. The framework includes
modules that support raw data import and processing, mutational
signature extraction, and results interpretation and visualization. The
framework accepts widely used file formats storing information about
DNA variants, such as Variant Call Format files. The framework performs
Non-Negative Matrix Factorization to extract mutational signatures
explaining the observed set of DNA mutations. Bootstrapping is
performed as part of the analysis. The framework supports
parallelization and is optimized for use on multi-core systems. The
software was described by Fantini D et al (2020)
< doi:10.1038/s41598-020-75062-0> and is based on a custom R-based
implementation of the original MATLAB WTSI framework by Alexandrov LB
et al (2013) < doi:10.1016/j.celrep.2012.12.008>.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
