| Name : R-scTenifoldKnk
| |
| Version : 1.0.1
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp153.3.7
| Date : 2024-06-14 11:49:56
|
| Group : Development/Libraries/Other
| Source RPM : R-scTenifoldKnk-1.0.1-lp153.3.7.src.rpm
|
| Size : 0.62 MB
| |
| Packager : (none)
| |
| Summary : In-Silico Knockout Experiments from Single-Cell Gene Regulatory Networks
|
Description :
A workflow based on \'scTenifoldNet\' to perform in-silico knockout
experiments using single-cell RNA sequencing (scRNA-seq) data from
wild-type (WT) control samples as input. First, the package constructs
a single-cell gene regulatory network (scGRN) and knocks out a target
gene from the adjacency matrix of the WT scGRN by setting the gene’s
outdegree edges to zero. Then, it compares the knocked out scGRN with
the WT scGRN to identify differentially regulated genes, called
virtual-knockout perturbed genes, which are used to assess the impact
of the gene knockout and reveal the gene’s function in the analyzed
cells.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Leap_15.3/x86_64 |
