| Name : R-dfped
| |
| Version : 1.1
| Vendor : obs://build_opensuse_org/devel:languages:R
|
| Release : lp154.5.1
| Date : 2024-09-17 12:58:22
|
| Group : Development/Libraries/Other
| Source RPM : R-dfped-1.1-lp154.5.1.src.rpm
|
| Size : 0.18 MB
| |
| Packager : https://www_suse_com/
| |
| Summary : Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
|
Description :
A unified method for designing and analysing dose-finding trials in
paediatrics, while bridging information from adults, is proposed in the
\'dfped\' package. The dose range can be calculated under three
extrapolation methods: linear, allometry and maturation adjustment,
using pharmacokinetic (PK) data. To do this, it is assumed that target
exposures are the same in both populations. The working model and prior
distribution parameters of the dose-toxicity and dose-efficacy
relationships can be obtained using early phase adult toxicity and
efficacy data at several dose levels through \'dfped\' package. Priors
are used into the dose finding process through a Bayesian model
selection or adaptive priors, to facilitate adjusting the amount of
prior information to differences between adults and children. This
calibrates the model to adjust for misspecification if the adult and
paediatric data are very different. User can use his/her own Bayesian
model written in Stan code through the \'dfped\' package. A template of
this model is proposed in the examples of the corresponding R functions
in the package. Finally, in this package you can find a simulation
function for one trial or for more than one trial. These methods are
proposed by Petit et al, (2016) < doi:10.1177/0962280216671348>.
|
RPM found in directory: /packages/linux-pbone/ftp5.gwdg.de/pub/opensuse/repositories/devel:/languages:/R:/autoCRAN/15.4/x86_64 |
